Nebivolol vs Metoprolol

2 Nov, 11

ENESYS Study: Nebivolol superior to Metoprolol in Improving Left Ventricular Dysfunction in Hypertensives with LVH

Aim

To compare the effects of nebivolol- with metoprolol-based treatment in patients with mild-to-moderate hypertension and left ventricular hypertrophy (LVH).

Fifty patients with mild-to-moderate hypertension (daytime ambulatory blood pressure >140 &/or >90 mmHg) and LVH (left ventricular mass index >125 g/m² for men and >110 g/m² for women) and no coronary heart disease (CHD)

Study Groups

Nebivolol 5 mg + Hydrochlorothiazide 25 mg (n=25)
Metoprolol 100 mg + Hydrochlorothiazide 25 mg (n=25)

If necessary, quinapril (ACE-I) 10-40 mg/day was added

Assessment

Doppler echocardiography, at rest and during dobutamine stress test

Study Duration

6 months

Results

Nebivolol and Metoprolol reduced BP and Heart Rate to a similar extent

Improvement in LV function was significantly greater with Nebivolol vs. Metoprolol

Parameters	Nebivolol	Metoprolol
Increase in mean Longitudinal ETDE (%)	16% *	9%
Increase in FPV (%)	34% *	0
Increase in ejection time (%)	5% *	0
Increase in mean longitudinal displacement (%)	10% *	0