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3 Feb, 26
This IDSA guideline outlines evidence‑based empiric and definitive antibiotic selection for complicated UTI, emphasizing severity‑based therapy, resistance risk assessment, patient‑specific factors, and stewardship‑driven narrowing once cultures return.
3 Feb, 26
This IDSA guideline reviews evidence on IV‑to‑oral antibiotic transition in complicated UTI, outlining when clinically improving patients may safely switch to effective oral agents to reduce IV‑related risks, costs, and hospitalization.
23 Jan, 26
BMC Infect Dis.
- Diabetic patients showed higher urinary tract infections (UTI) prevalence (43.3% vs 28.5%; OR 1.98, p = 0.020), especially ≥46 years (OR 2.33, p = 0.009)
- Type 2 diabetics had more UTIs (48.9%) than type 1 (28.1%)
- E. coli predominated. Antibiotic resistance was high (86.7%), greater in diabetics (92.5% vs 75%), and statistically significant for E. coli
22 Jan, 26BMC Pregnancy Childb...
- A district-level study in Bihar (India) analyzed ambient temperature and stillbirth rates using fixed-effects and distributed lag models
- Results showed a U-shaped association: both high (~35 °C) and low (~18 °C) exposures increased stillbirth risk by 7–14%
- Findings highlight pregnancy’s thermal sensitivity and need to integrate climate factors into maternal health policy for resilience.
21 Jan, 26Diabetes Res Clin Pr...
- In a cohort of 114293 Chinese adults (mean follow-up 3.1 y; 2435 T2DM cases) IR indices (TyG, TyG-BMI, TG/HDL-C, METS-IR) predicted diabetes risk, strongest in non-overweight (reverse gradient for all indices)
- Adjusted HRs for TyG were 4.60, 3.10, 2.62 in non-overweight, overweight, obese grps; TyG AUC (non-overweight): 76.74%
- Replication in 15453 Japanese confirmed findings, highlighting early risk in non-obese.
21 Jan, 26JAMA Cardiol.
- In 27748 women (median age 53 y, follow-up 27.8 y), Lp(a) >30 mg/dL or ≥75th percentile (31 mg/dL) raised 30 yr risk of major CV events/CHD
- Very high levels >120 mg/dL or ≥99th percentile (131 mg/dL) vs. <10 mg/dL or > 99th percentile vs 50th percentile (11 mg/dL) raised risk for MACE (HRs:1.54, 1.74), CHD (1.80, 2.06), ischemic stroke (1.41, 1.85), & CV death (1.63, 1.86)
- rs3798220 carriers had higher CV risk.
The management of pediatric asthma is evolving with newer approaches such as anti‑inflammatory reliever (AIR) therapy and SMART (single maintenance and reliever therapy) using budesonide–formoterol, which offer better outcomes than conventional treatment strategies. Novel breath‑actuated devices like the Synchrobreathe, known for their ease of use and training in adults with obstructive airway diseases, may also be p...
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