HbA1c Trajectories Among Children and Young People with Type 2 Diabetes in Multi-ethnic Singapore

Presenter: J.H.M. Yung

This multi-ethnic cohort analyzed HbA1c trajectories in 138 children and young people (CYP) with type 2 diabetes (T2D) in Singapore (47% male; 61% Chinese, 24% Malay, 13% Indian). Mean age at diagnosis was 13.8±2.2 years, with mean HbA1c 10.1±2.9% and BMI z-score 1.64±0.70.      

Over a median follow-up of 3.5 years, four distinct HbA1c trajectories were identified. Indian (OR=2.78; p=0.04) and Malay (OR=2.64; p=0.01) CYP were significantly more likely to exhibit worsening glycaemic trajectories compared to Chinese. Insulin therapy was likely to be started at diagnosis for CYP 3 or 4 (HbA1c 9.1%-10.5% at diagnosis), OR 3.69). CYP’s sex, age or BMI z-score were not associated with identified HbA1c trajectories.

These findings may guide clinicians on treatment strategies for young-onset T2D.

EASD 2025, 15th – 19th Sept 2025, Vienna, Austria.