Outpatient Management of Early Pregnancy Loss
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12 Dec, 12

Outpatient Management of Early Pregnancy Loss

Introduction

The management of early pregnancy loss (EPL) used to be based largely in the hospital setting, but it has shifted to the outpatient setting, allowing women to remain under the care of their doctor throughout the miscarriage process.

Unless products of conception are seen, the diagnosis of miscarriage is made with ultrasonography and, when ultrasonography is not available or is nondiagnostic, with measurement of ?-hCG levels. Management options for EPL include expectant management, medical management with misoprostol, and uterine aspiration.

This leaflet gives an overview of the key recommendations for practice, factors associated with EPL, miscarriage myths, definitions and ultrasound findings in subcategories of EPL, and evaluation of first-trimester bleeding.

Miscarriage Myths: Factors Mistakenly Associated with EPL

  • Air travel
  • Blunt abdominal trauma
  • Contraceptive use (including oral contraceptive, intrauterine device [before pregnancy], implants, spermicides)
  • Stress
  • Human papillomavirus vaccination (bivalent 16/18)
  • Previous first-trimester elective abortion
  • Sexual activity
  • Exercise (continuing exercise at pre-pregnancy levels)

Factors Associated with EPL

  • Advancing maternal age
  • Reproductive tract abnormalities: congenital uterine anomalies, leiomyoma, shortened cervix, uterine adhesions
  • Caffeine use (with dose-response)
  • Cigarette smoking (more than 10 cigarettes / day)
  • Cocaine use
  • Maternal celiac diseases: antiphospholipid antibody syndrome, polycystic ovary syndrome, possibly celiac disesae, thyroid disease or uncontrolled diabetes mellitus
  • Maternal infections: Chlamydia (conflicting evidence), Listeria, syphilis, toxoplasmosis, vaginal Mycoplasma or Ureaplasma
  • Medications: itraconazole,methotrexate, non-steroidal anti-inflammatory drugs, paroxetine, retinoids, venlafaxine
  • Obesity
  • Previous EPL
  • Alcohol use (moderate)
  • Toxins and occupational exposures: ionizing radiation, pesticides, unscavenged anesthetic gases

Definition & Ultrasound Findings in Subcategories of EPL

Key Recommendations for Practice

Evaluation of First-trimester Bleeding

Evaluation of First-trimester Bleeding: No Intrauterine Pregnancy on Ultrasonography