REGRESS (Regression Growth Evaluation Statin Study) Sub-study

18 Aug, 10

REGRESS (Regression Growth Evaluation Statin Study) Sub-study

Introduction

B-mode ultrasound assessment of pravastatin treatment effect on carotid and femoral walls and its correlations with coronary arteriographic findings. A report of the Regression Growth Evaluation Statin Study (REGRESS).

Purpose

To determine the effects of pravastatin on carotid and femoral artery walls.

Design

As per REGRESS. Imaging of carotid and femoral arteries by B-mode ultrasound at baseline, 6,12, 18, and 24 months.

Patients

255 patients that were part of REGRESS.

Follow-up

24 months (ultrasound findings)

Treatment Regimen

As per REGRESS

Results

Baseline IMT (intimal thickness) was 0.86 + 0.33 mm. IMT decreased 0.05 + 0.20 (SEM) mm in patients receiving pravastatin; IMT was unchanged in the placebo group (p=0.0085 pravastatin vs placebo).
Maximal IMT was 1.07 + 0.43 mm and decreased by 0.05 + 0.22 mm with pravastatin but increased by 0.01 + 0.21 mm in the placebo patients.

Conclusion

Pravastatin decreased intimal medial thickening of carotid and femoral arteries.

J Am Coll Cardiol 1998;31:1561-7