Introduction

The prevalence of erectile dysfunction (ED) is increasing and has an adverse effect on the marital life of men. Many therapies such as intracavernosal injection, hormone therapy, phosphodiesterase 5 inhibitors and vacuum erection devices are currently being used in the management of ED. However, they are not completely effective in curing this condition. Platelet-rich plasma (PRP) contains several bioactive substances that help in cell proliferation, vascular formation, collagen production and tissue repair and might have a potential for treating ED.

Aim

To assess the efficacy of platelet-rich plasma (PRP) in the treatment of erectile dysfunction (ED).

Method

Study Design

• Systematic review and meta-analysis of randomized controlled trials (RCTs)

Treatment Strategy

• Relevant RCTs were identified using the databases of PubMed, Cochrane. Embase and Web of Science
• The data was analysed and differences in minimal clinically important difference (MCID) and International Index of Erectile Function (IIEF) between baseline and the 1^st, 3^rd and 6^th month was evaluated

Endpoints

• Difference in MCID from baseline at 1^st, 3^rd and 6^th month
• Difference in IIEF from baseline at 1^st, 3^rd and 6^th month

Results

• Meta-analysis included 4 RCTs comprising 343 men with ED
• The therapeutic effect of PRP was superior and significant in the 1^st and 6^th month as compared to placebo (p=0.03 and p=0.008 respectively), as indicated by the difference in MCID
• The difference in MCID was insignificant at 3^rd month; p=0.19
• Statistically significant differences in IIEF were noted at all the 3 timepoints in the PRP groups as compared to placebo; highlighting the superior efficacy of PRP after 1, 3 and 6 months of treatment (p<0.00001)

Conclusion

• Treatment with platelet-rich plasma (PRP) demonstrated significant improvements in men with erectile dysfunction as compared to placebo and may be a promising alternative in the treatment of ED.

Aging Male. 2024. 27:1;2358944. Doi: 10.1080/13685538.2024.2358944.