WCO IOF- ESCEO 2025: Prevalence of Osteoporosis, Low Trabecular Bone Score, and Fracture Risk in Rheumatoid Arthritis Patients

Presenter: T. K. H. Nguyen

Rheumatoid arthritis (RA) patients face high osteoporosis and fracture risk, amplified by glucocorticoid use. A cross-sectional study evaluated the prevalence of osteoporosis, low Trabecular Bone Score (TBS), fracture risk, and treatment indications in 131 RA patients (83% female, mean age 60.2 years).

Osteoporosis prevalence was 22.1%, osteopenia 60.3%, and fractures occurred in 21.4%. Low TBS was observed in 26%, with poor concordance between TBS and BMD. However, combining  fracture risk tools (FRAX) identified 32.8% high risk patients. Significant concordance between FRAX and TBS-adjusted FRAX predicted additional osteoporotic and hip fractures in 5.3% and 31% high-risk osteopenic patients. More than half of RA patients (58.8%) required treatment as per Asia Pacific Consortium on Osteoporosis guidelines. The study emphasized comprehensive assessment using TBS, BMD, and FRAX for enhanced fracture risk stratification in RA.

World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, April 10-13, 2025, Rome, Italy