Tenofovir disoproxil fumarate is a highly selective, potent inhibitor of HBV replication with a high genetic barrier to resistance. It is recommended as first-line option in nucleoside-naive patients with chronic HBV infection and is a useful alternative in lamivudine-resistant patients. This slideset enumerates the efficacy, safety, indications, dosing and place in therapy of tenofovir in Hepatitis B.