Nebivolol vs Carvedilol

2 Nov, 11

Nebivolol is as Effective as Carvedilol in Treatment of Hypertensive CHF Patients

Aim

To compare the effects of long-term treatment of nebivolol with carvedilol on left ventricular ejection fraction (LVEF), exercise capacity and clinical outcomes in hypertensive CHF patients.

Study Patients

Hypertensive CHF patients, with LVEF < 40% and in New York Heart Association (NYHA) functional class I, II or III (N = 160)

Study Groups

Nebivolol (n = 80)
Carvedilol (n = 80)

Nebivolol was initiated at 1.25 mg/day. If tolerated, dose was sequentially up-titrated every week. Target dose of 10 mg/day was reached by week 4.

Carvedilol was initiated at 3.125 mg twice daily. If tolerated, dose was sequentially up-titrated every week. Target dose of 50 mg/day was reached by week 6.

Target dose of Nebivolol and Carvedilol was reached in 60 and 57 patients, respectively.