In your experience, do adults born extremely preterm show a higher burden of anxiety and depression compared to those born at term?
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In 701 DPP participants with T2D, younger-onset was linked to higher FPG, BMI, DBP, lower HDL, smaller BP/lipid improvements, and rising HbA1c over 7.9 years. Older-onset had higher SBP, lower eGFR, and stable glycaemia. Younger-onset were more often on glucose-lowering drugs. Findings highlight worse metabolic progression in early-onset T2D despite better renal and BP profiles.
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Neutrophil-to-lymphocyte ratio (NLR >4.8) was a robust predictor of worse outcomes in patients with localized cutaneous melanoma (stage I-II), found a study. Higher NLR corresponded to poorer melanoma-specific survival (HR 3.2) and higher risk of distant metastases (HR 2.0). Elevated NLR was also linked to tumor features like ulceration, higher mitotic index of > 5 mitoses/mm², and head or neck location.
Adults born extremely preterm (≤ 28 weeks) face a four-fold higher risk of major depressive disorder (OR 4.14) and a five-fold higher risk of anxiety disorder (OR 5.17) compared to term births. The depression link weakened after adjusting for maternal smoking and alcohol intake. Childhood emotional and peer-related issues further raised the risk of adult depression among those born preterm.
A 9-year analysis of CHARLS data revealed that sarcopenic adults (≥ 45 years) were at a higher risk of hip fracture than those without it (7.2% vs. 3.8%). Sarcopenia independently raised hip fracture risk by 33% (aOR 1.33), even after adjusting for lifestyle factors and comorbidities. Findings highlight the need for early identification and prevention of sarcopenia to reduce fracture burden.
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