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18 Nov, 25
The ESI obesity management guidelines are based on the fast-changing obesity epidemiology & pharmacological options. The novel concepts in the psycho-social aspects & medication counselling of obesity management have also been explored.
18 Nov, 25
The prevalence of obesity has been increasing rapidly in India as well as globally. The clinical practice guidelines from the Endocrine Society of India (ESI) guide the healthcare providers on optimizing the management of obesity.
25 Nov, 25
BMC Infect Dis.
- Fluconazole achieved 82.7% (N=374) success in pulmonary cryptococcosis
- In 34 failures, 19 continued fluconazole and 15 switched to voriconazole
- On day 60, voriconazole showed higher response (66.7% vs 15.8%, p=0.002) indicating superior short-term efficacy but long-term (day 180) rates were similar (66.7% vs 68.4%, p=0.914)
- Adverse events were comparable (20% vs 15.8%; p = 0.439)
25 Nov, 25Int J Pediatr Otorhi...
- This study assessed if AR influences secondary adenoidectomy rates after primary adenoidectomy surgery in children
- No significant difference was found upto 0.5 years post-adenoidectomy
- However, AR patients showed significantly higher risk from 6 months onward, with p-values <0.0001 across multiple intervals up to 7+ years
- AR substantially increases long-term likelihood of secondary adenoidectomy after initial p...
21 Nov, 25Cureus.
- Candidemia occurrence: 0.73% of 16,040 blood cultures
- C. tropicalis (32.2%) predominated and had highest azole resistance, esp. posaconazole (78.95%)
- C. albicans had posaconazole resistance (17.65%), while C. parapsilosis had fluconazole resistance (25%)
- C. auris exhibited multidrug resistance (fluconazole 87.5%, caspofungin 50%)
- Rising azole resistance requires rapid identification and targeted therapy.
20 Nov, 25Diabetes Obes Metab.
- The study ascertained the link between 75 serum metabolites & incident diabetic foot complications in 637 T1DM patients (median age 55, HbA1c 8%, diabetes duration of 35 years)
- Threonine & succinic acid were linked to prevalent amputations (p < 0.05), ribonic acid (HR:1.02) & nonanoic acid (HR:0.96) were linked to incident ulcers
- The link between ribonic acid & DFU was also validated in an independent cohort.
19 Nov, 25
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