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2 Dec, 25
The AACE Algorithm on obesity/ABCD care provides detailed guidance on various aspects of management such as screening, diagnosis, tailored plans, therapy response, medication hierarchies, individualized pharmacotherapy, & FDA-approved treatments.
2 Dec, 25
Blood glucose–lowering therapy begins with lifestyle modification and metformin, with SGLT2 inhibitors or GLP-1 receptor agonists added based on cardio-renal risk and obesity status. Insulin is initiated when glycaemic targets are not achieved with optimized non-insulin therapy, with ongoing monitoring and adjustment through intensification or deintensification to maintain safety and control.
4 Dec, 25
J Intensive Care Med...
- In sepsis patients, physical assessments at ICU discharge predicted physical dysfunction/death within a year of discharge
- Lower MRC (Medical Research Council) score (OR 0.98, cut-off 46), handgrip strength (OR 0.95, cut-off 12 kg), & Barthel index (BI, OR 0.96, cut-off 15) independently predicted these events; BI emerged as the best (AUC 0.718)
- BI & hand grip strength were linked to cognitive dysfunction.
4 Dec, 25Br J Dermatol
- Routine SPF 50+ use for 1 yr resulted reduced serum 25(OH)D vs discretionary use (–5.2 nmol/L.
- Vitamin D deficiency was more common in the intervention grp (45.7%) than in the control grp (36.9%), with a prevalence ratio of 1.33.
- Regular use of high sun protection factor sunscreen may require vit D supplementation to prevent deficiency.
3 Dec, 25BMC Infect Dis.
- Systematic review of 36 studies in low- and middle-income countries found indoor air pollution strongly linked to acute respiratory infections in under-five children (pooled prevalence 13.56%)
- Major risk factors: No kitchen window (OR=4.47), traditional stoves (OR=2.53), secondhand smoke (OR=1.19), unclean fuels (OR=1.16)
- Other factors: Diarrhea (OR = 3.76), and stunting (OR = 1.16) also increased risk.
3 Dec, 25JAMA Neurol.
- Obstructive sleep apnea (OSA) was linked to higher incidence of Parkinson disease (PD): 1.61 new cases/1000 at 6y from diagnosis vs non-OSA, even after adjusting for body mass index, comorbidities, psychiatric conditions, & medications in 11.3M veterans; risk was greater in women
- Early treatment with continuous positive airway pressure reduced PD cases, suggesting OSA to be an independent modifiable PD risk factor.
19 Nov, 25
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