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11 Mar, 26
New guidelines on pulmonary embolism (PE) offer evidence based recommendations for evaluating, managing, and following up adults with acute PE. Endorsed by eight societies, it stresses multidisciplinary care across emergency, inpatient, & outpatient settings.
26 Feb, 26
ADA 2026 outlines the standards for obesity pharmacotherapy. It recommends combining person-centered medication with lifestyle changes for adults with obesity. It details weight-loss targets and drug benefits for comorbidities
16 Mar, 26
Endocrinol Diabetes ...
- A systematic review & meta-analysis of 23 RCTs compared SGLT 2i+metformin vs. other metformin containing oral dual therapies in T2DM
- HbA1c reduction was comparable at 24/52 weeks, at 52 weeks, patients on SGLT 2i+metformin had lower hypoglycemia risk (RR 0.27) & greater body weight reduction (MD –2.59 kg), but increased genital infection risk (RR 5.08)
- Other safety outcomes were comparable.
16 Mar, 26Lancet Infect Dis.
- Meta analysis showed that typhoid caused substantial morbidity; delirium/confusion occurred commonly (26.5%)
- Typhoid case fatality ratio (CFR) was 2.1% & typhoid intestinal perforation CFR was 16.3%; highest in Africa (4.7%), followed by America (2.9%) and Asia (1.2%)
- Higher typhoid CFR was seen in facility-based vs. community-based recruitment sites (2.3% vs. 0.9%) & among those aged <15y (2.7%)
13 Mar, 26RMD Open
- Exercise gives small, short term pain relief in knee osteoarthritis (OA) (−10.8 to −12.4) with very low certainty
- Hip OA shows negligible benefit (−6.7), and hand OA small effects (−10.0)
- Pain and function outcomes were similar to those achieved with education intervention, analgesics, injections and manual therapy.
12 Mar, 26JAMA Cardiol.
- In a Danish cohort (n=38455; biomarker subcohort n≈2,056, age 30.4 y), 28 women (1.4%) developed CVD over median 11.9 y
- Third trimester hs cTnI & soluble fms-like tyrosine kinase-1 (sFlt-1), maternal age, & HDPs independently predicted risk, a week 29 model (age+sFlt 1) improved discrimination vs. age alone (ΔAUC 0.16)
- Pregnancy biomarkers may be good sex specific predictors for long term CVD prevention.
2 Mar, 26
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23 Feb, 26
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