This is the first edition of this guideline. It addresses the management of thyroid disease in women of childbearing age, providing evidence-based best practices and consensus opinions from a multidisciplinary team. It aims to optimize care before conception, during pregnancy, and postpartum, highlighting the importance of appropriate treatment to prevent adverse effects on the pregnancy and fetus.

Rapid diagnostic tools in microbiology vary in speed, cost, and capability. While biochemical tests offer full ID + AST, MALDI-TOF enables rapid ID, and molecular tests detect resistance genes. Advanced tools like flow cytometry, microfluidics, and nanomotion sensors promise faster AST. Yet, impact depends on timely lab processes, reporting, and clinical response.

Metabolic syndrome and insulin resistance correlated with impaired executive function in women after preeclampsia. Women with metabolic syndrome had over 4 times higher odds of impaired executive function (OR 4.20), while those with insulin resistance had 7 times higher odds (7.26) and accounted for 56% of cognitive impairment. Obesity (OR 3.86) & hyperglycemia (OR 2.96) were also linked to cognitive decline.

Patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) and coexisting mental health disorders had worse in-hospital outcomes, a large US study reported. Compared to matched peers, these patients had higher in-hospital mortality (2.26% vs. 1.21%), greater odds of sudden cardiac arrest (1.51% vs. 0.65%), pulmonary embolism (1.54% vs. 0.65%), & acute kidney injury (25.45% vs. 20.24%).

A study suggested that gait impairments may signal Alzheimer's disease (AD) in adults with Down syndrome (DS). Over 32 months, higher amyloid beta & neurofibrillary tangle levels & smaller hippocampal volumes were tied to greater gait declines. Those with dementia had more notable gait deterioration. Cognitive decline also correlated with gait deterioration, highlighting gait assessments as an effective screen for AD

Patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic alcohol-associated liver disease (MetALD) faced an elevated risk of dementia. In a study spanning over 7.4 million person-years, MASLD was linked to a 10% higher risk of Alzheimer's disease (AD) and a 20% higher risk of vascular dementia (VaD). MetALD showed a 53% higher risk of VaD, while AD risk increased after 3 years.