Factors Increasing Risk of Secondary Osteoarthritis

Primary and secondary OA are caused by different factors. However, the resulting pathology is the same: a degenerative phenomenon, complicated by inflammatory reactions.

Several disorders are well recognized as causes of secondary osteoarthritis, and they can be divided into 4 main categories:

There are few other conditions/disorders that increase the risk of osteoarthritis, however the evidence is limited. These are Congenital joint disorders, Avascular necrosis, Infectious arthritis, Paget disease, Osteopetrosis, Osteochondritis dissecans, Metabolic disorders (Hemochromatosis, Wilson’s disease), Hemoglobinopathy, Ehlers-Danlos syndrome, or Marfan syndrome.


  1. Saxon L, et al. Sports participation, sports injuries and osteoarthritis: implications for prevention. Sports Med. 1999 Aug;28(2):123-35.
  2. Teng GG, et al. Gout and risk of knee replacement for severe knee osteoarthritis in the Singapore Chinese Health Study. Osteoarthritis Cartilage. 2017;25(12):1962-1968.
  3. Sen R, Hurley JA. Osteoarthritis. . In: StatPearls . Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from:  https://www.ncbi.nlm.nih.gov/books/NBK482326/