Cervical Ripening using Vaginal Misoprostol before Hysteroscopy: A Double-Blind Randomized Trial

6 Nov, 10

Cervical Ripening Using Vaginal Misoprostol before Hysteroscopy: A Double-Blind Randomized Trial

Aim

To evaluate the use of vaginal misoprostol to decrease both the force required to dilate the cervix and the pain experienced during a hysteroscopy.

Material and Methods

This was a randomized clinical trial.
N = 101 patients needing a diagnostic hysteroscopy were randomized to receive 12 to 24 hours before a hysteroscopy -
- 400 mcg of vaginal misoprostol - N = 50; and
- Vaginal placebo - N = 51.
Patient characteristics were similar in the 2 groups.

Results

The force needed to dilate the cervix was assessed by a tonometer, and pain was measured by a visual analog scale.

The main side effect reported with the use of the drug was pelvic cramping.

Conclusion

The use of 400 mcg of vaginal misoprostol 12 to 24 hours before hysteroscopy reduces the pain and the force needed to dilate the cervix, with only mild side effects.

J of Min Invasive Gynecology, 2008; 15 (6): 739-744