Sex Differences in HIV Persistence and Reservoir Size during Aging

Clin Infect Dis

In contrast to men, where the HIV reservoir steadily declines with aging, the HIV reservoir in women is more dynamic. Total HIV DNA (including intact and defective genomes) declines more slowly in women than in men, while the inducible HIV RNA + reservoir, which is highly enriched in replication competent virus, increases in women after menopause.